"Plant" View: What are the characteristics of the new generation of crystal ball probiotics?

The article is reproduced from: Xinoya

      As the "second brain of the human body", the health of the intestine is closely related to the overall health of the human body. At present, probiotic dietary supplements are receiving more and more attention and attention. In 2020, the "Expert Consensus on the Clinical Application of Chinese Microecological Regulators (2020 Edition)" issued by the Microecology Branch of the Chinese Preventive Medicine Association pointed out that the effect of probiotics is strain-specific and dose-dependent, and the supplemental dose of probiotics is usually limited to the range of 108-1011 CFU. However, the fragile physiological and biochemical properties of probiotics make them intolerant to multiple factors such as temperature, moisture, and gastric digestive environment, which ultimately affects the stability of the product and its effect. Therefore, the development of new complex preparations of probiotics that can deliver high viable counts to the intestine plays an important role in improving product quality and enhancing product value.

      Ningbo Sinoa Marine Biotechnology Co., Ltd. independently developed a new generation of highly active patented microcrystalline probiotics - CrystoGen™ microcrystalline probiotics (a strain of Bifidobacterium longum that can produce polysaccharides and the application of its polysaccharides in crystal probiotic preparations, patent number: ZL 2023 1 0094263.2). Its high activity, water and oxygen isolation, targeted delivery, and slow and controlled release characteristics are superior in improving the shelf life stability and performance of probiotic products, and can better meet the intestinal delivery and intestinal slow and controlled release and colonization of probiotics. Based on CrystoGen™ microcrystalline probiotics, through continuous technological breakthroughs, the development of CrystoGen™ microcrystalline probiotics suitable for water phase has also been achieved, expanding the application of microcrystalline probiotics in liquid preparations such as yogurt and beverages.

CrystoGen™ Microcrystalline Probiotic Technology

      CrystoGen™ microcrystalline sphere multilayer microcapsule technology (a polysaccharide-producing Bifidobacterium longum variant and its polysaccharide in crystal sphere probiotic preparations, patent number: ZL 2023 1 0094263.2,) developed by Ningbo Sinoya Marine Biotechnology Co., Ltd. with its own patented technology has excellent performance in improving the shelf life stability and water-soluble stability of strains, and can better meet the strain specificity and dose-dependency requirements of probiotic product development.

Its performance is as follows:

1. Highly active, the actual number of live bacteria can reach 600 billion CFU/g

2. Resistant to gastric acid: After entering the body, the microspheres can effectively resist the erosion of gastric acid and protect the live bacteria from being destroyed, thus ensuring that the live bacteria can reach the intestines smoothly.

3. Intestinal sustained release: slow and controlled release, effective colonization

4. Smaller diameter: particle size 0.5-2.5mm, easy to swallow, convenient for more market applications

5. Water-soluble and stable: Microcrystalline spheres can maintain their structure and activity for a long time in water and will not lose their effect due to dissolution. This stability helps ensure the continuous effect of microcrystalline spheres in the intestine.

6. Encapsulation of other active ingredients: Microcrystalline sphere encapsulation technology can be widely used in the encapsulation of functional foods to achieve water and oxygen isolation, stomach acid resistance, sustained release control, flavor shielding, and reduction of mutual interference between other substances in the formula, etc., to expand the application development of products.

Ningbo Sinoa Company Profile

      Ningbo Sinoa Marine Biotechnology Co., Ltd. was founded by Dr. Zhu Hui and is committed to the innovative development of marine biological resources and the integrated development of raw materials and preparations. The company uses synthetic biology technology to deeply explore marine biological germplasm resources, develop core functional ingredients such as marine enzyme preparations, marine microecological preparations and marine polysaccharides, and combine intestinal controlled-release complex preparation technology to provide intestinal precision nutrition and precision medicine solutions to serve human health.

Core Products:

●CrystoGen™ Highly Active Crystal Ball Probiotics

●Zoomzyme™ Customized Digestive Enzyme

●CrystoLac™ Highly Active Lactase

Business scope: Digestive enzyme probiotic raw materials, CrystoGen™ highly active crystal ball probiotics, ODM

 

Human in vitro simulated gastrointestinal digestive system

      The in vitro simulated digestive system simulates the digestive process of the human gastrointestinal tract and the digestion and absorption in vivo under in vitro conditions. It is an in vitro model used to predict or evaluate the digestibility, bioavailability, release kinetics and structural changes of compounds. The in vitro simulated digestive system can completely or partially replace in vivo experiments, with the advantages of reducing costs and time, improving experimental repeatability and accuracy, and manual monitoring. The in vitro simulated digestive system can detect the entire digestive process of probiotics in the gastrointestinal tract at any time, which is helpful for the study of the bioavailability and function of probiotic products.

It can provide professional gastrointestinal digestion simulation experiments and help the research of probiotics and functional foods.

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‼ Sinoa Shanghai FIA Exhibition 2024
⏰Time: June 19-21, 2024
Booth: Hall 2.1 21J15
📌Venue: Shanghai National Exhibition and Convention Center

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