NEWGENBIO ^{Registered trademark} Professional Solutions for Lactose Intolerance

Lactose intolerance

Dairy products offer significant health benefits; the lactose naturally present in mammalian milk facilitates the absorption of calcium and zinc [2]. Insufficient dairy intake can lead to a variety of health problems. According to the “2015–2017 China National Nutrition and Health Surveillance Report,” the average daily milk consumption per capita in China is less than one-tenth of the level recommended in the “Dietary Guidelines for Chinese Residents” [1]. According to the World Health Organization, approximately 70% of adults worldwide are affected by lactose intolerance, a figure that rises to as high as 95% in China; consequently, most Chinese individuals are unable to digest the lactose in dairy products. Lactose intolerance is a widespread global health issue, primarily caused by insufficient lactase activity in the small intestine, which prevents the complete breakdown and absorption of ingested lactose, resulting in a range of gastrointestinal discomforts. In the “Expert Consensus on Lactose Intolerance and Scientific Milk Consumption,” the expert working group of the Chinese Nutrition Society has put forward the following three recommendations for individuals with lactose intolerance:

1. Limit your intake of dairy products per serving and opt for low-lactose varieties whenever possible. Only if you are extremely sensitive to lactose should you choose lactose-free dairy products.
2. Adjust the way dairy products are consumed by eating them together with other foods.

3. Choose lactase or other probiotic products that can improve gut health.

NEWGENBIO ^{Registered trademark} Acidic lactase

Since its inception, Xinoya has adhered to: Research-driven, technology-first, continuous investment, and long-termism the company’s guiding philosophy. Centered on the critical area of acidic lactase, the company has continuously conducted systematic research on strain screening, enzymatic characteristics, and application suitability, and has achieved proprietary intellectual property rights in these areas.

Xinoya selects Aspergillus oryzae, an edible-grade microorganism that has been used for food fermentation worldwide for many years, as the source of acidic lactase, thereby providing a solid foundation for product safety and consistent, stable supply. In addition, the company holds an invention patent. “A Strain of Aspergillus oryzae Producing Acidic Lactase and Its Applications” (Patent No.: ZL 2023 1 0094261.3 ), a stable and highly adaptable acidic lactase solution has been developed using Aspergillus oryzae as the source, providing a technological approach that better mimics the real digestive environment for individuals with lactose intolerance.

Currently, NEWGENBIO ^{Registered trademark} The LAC series covers a wide range of raw materials, including solids, liquids, and glycerin-free liquids; among them, the highest-grade solid formulation, LAC200, achieves an activity level of 200,000 ALU/g (FCC VII assay) , the highest-grade liquid LACN70, with maximum activity reaching 70,000 ALU/mL (FCC VII assay) 。

The LAC series is widely applicable in areas such as pharmaceutical formulations, dietary supplements, formulated milk powders, and pet nutrition, and can be used to develop a variety of dosage forms, including tablets, powders, hard capsules, soft capsules, and microcapsules.

NEWGENBIO ^{Registered trademark} LAC is also the only lactase in China currently submitted for FDA GRAS status and has successfully completed FDA DMF registration in the United States, NEWGENBIO. ^{Registered trademark} LAC boasts superior raw-material quality that meets internationally recognized regulatory standards and has already captured a significant share of the lactase market in the United States, Europe, the Middle East, and other regions.

References:

1. Zhao Liyun, Ding Gangqiang, Zhao Wenhua, Yu Dongmei, Zhang Jian, Yang Lichen, et al., Monitoring Report on the Nutritional and Health Status of Chinese Residents, 2015–2017. (People’s Medical Publishing House), p. 317.
2. Kalathinathan P, Sain A, Pulicherla K, Kodiveri Muthukaliannan G. A Review on the Various Sources of β-Galactosidase and Its Lactose Hydrolysis Property. Curr Microbiol 2023;80:122.