NEWGENBIO ^® Professional Solution for Lactose Intolerance

Lactose intolerance

Dairy products offer significant health benefits. Lactose, naturally present in mammalian milk, can enhance the absorption of calcium and zinc [2]. Insufficient intake of dairy products may lead to a variety of health problems. According to the “2015–2017 China National Nutrition and Health Status Monitoring Report,” the average daily milk consumption per capita in China is less than one-tenth of the amount recommended by the “Chinese Dietary Guidelines for Residents” [1]. According to statistics from the World Health Organization, approximately 70% of adults worldwide are affected by lactose intolerance; in China, this proportion rises to as high as 95%. Consequently, most Chinese people are unable to digest lactose found in dairy products. Lactose intolerance is a globally prevalent health issue whose underlying cause is insufficient activity of lactase in the small intestine, resulting in incomplete breakdown and absorption of ingested lactose and subsequently triggering a range of gastrointestinal discomforts. In the “Expert Consensus on Lactose Intolerance and Scientific Milk Consumption,” the expert working group of the Chinese Nutrition Society offers the following three recommendations for individuals with lactose intolerance:

1. Control your intake of dairy products per serving and, whenever possible, opt for low-lactose dairy products. Only if you are extremely sensitive to lactose should you choose lactose-free dairy products.
2. Adjust the way you consume dairy products by consuming them together with other foods.

3. Choose lactase or other probiotic products that can improve gut health.

NEWGENBIO ^® Acid lactase

Since its founding, XinoYaXinoYa has been committed to: Research-driven, technology-based, continuous investment, and long-term thinking. the company’s guiding principle. Centered on the key area of acidic lactase, the company continues to conduct systematic research on strain screening, enzymatic characteristics, and application compatibility, and has achieved proprietary intellectual property results.

Xinoya uses Aspergillus oryzae—a food-grade microorganism that has been used for food fermentation worldwide for a long time—as the source of acidic lactase, providing a solid foundation for product safety and a consistently stable supply. Furthermore, Xinoya already holds an invention patent. “A Strain of Aspergillus oryzae Producing Acidic Lactase and Its Applications” (Patent No.: ZL 2023 1 0094261.3 ), a stable and highly adaptable acidic lactase solution derived from Aspergillus oryzae has been developed, providing a technological approach that better mimics the real digestive environment for individuals with lactose intolerance.

Currently, NEWGENBIO ^® The LAC series covers a variety of raw materials, including solids, liquids, and glycerin-free liquids. Among them, the highest-grade solid formulation, LAC200, can achieve an activity level of... 200,000 ALU/g (FCC VII test) , the highest specification liquid LACN70, with a maximum activity of 70,000 ALU/mL (FCC VII assay) 。

The LAC series is widely applicable to fields such as pharmaceutical formulations, dietary supplements, formulated milk powders, and pet nutrition, and can be used to develop various dosage forms including tablets, powders, hard capsules, soft capsules, and microcapsules.

NEWGENBIO ^® LAC is also currently the only lactase in China that has been submitted for FDA GRAS approval and has successfully completed registration with the U.S. FDA DMF. NEWGENBIO ^® LAC boasts high-quality raw materials that meet the standards recognized by international regulatory systems, and already holds a significant commercial share in lactase markets across the U.S., Europe, the Middle East, and other regions.

Reference materials:

1. Zhao Liyun, Ding Gangqiang, Zhao Wenhua, Yu Dongmei, Zhang Jian, Yang Lichen, et al., 2015–2017 China National Monitoring Report on Nutrition and Health Status of Residents. (People's Medical Publishing House), pp. 317.
2. Kalathinathan P, Sain A, Pulicherla K, Kodiveri Muthukaliannan G. A Review on the Various Sources of β-Galactosidase and Its Lactose Hydrolysis Property. Curr Microbiol 2023;80:122.