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During the peak period of avian influenza, don't panic! Xinoa creates a "firewall" for your gut health.

2025

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During the peak period of avian influenza, don't panic! Xinoa creates a "firewall" for your gut health.

　What is H1N1? The severity of H1N1

　　Every year during the winter and spring seasons, influenza enters a high incidence period. According to the latest data from the Chinese Center for Disease Control and Prevention, the positive rate of influenza viruses is showing a significant upward trend, with over 99% being H1N1 influenza virus. H1N1 belongs to the RNA virus of the Orthomyxoviridae family, characterized by rapid transmission (mainly through droplets), a short incubation period (1 to 4 days), strong viral variability, and a tendency to induce complications (such as pneumonia) (DOI: 10.1093/oxfordjournals.aje.a112781).

Figure 1 The basic structure of the H1N1 virus and its TEM microscopic photo

Although H1N1 is relatively common among the public, its dangers should not be underestimated. Without timely and effective treatment, H1N1 can develop into severe pneumonia, leading to "white lung" and endangering life. According to the World Health Organization (WHO), approximately 1 billion people worldwide are infected with the influenza virus each year, including 3 to 5 million severe cases and 300,000 to 500,000 deaths (DOI: 10.1038/s41572−018−0002−y).

Recent studies have shown that H1N1 can also cause intestinal immune dysregulation, leading to elevated levels of various pro-inflammatory cytokines in colonic tissue (DOI: 10.3969/j.issn.1672−2302.2019.03.005), resulting in intestinal damage. For example, experts in disease monitoring pointed out in a study on H1N1 invading mice that H1N1 virus infection may cause intestinal inflammation and dysbiosis by altering gene expression levels in the colon and metabolic products in the cecum (DOI: 10.3784/jbjc.202303310136).

The key role of immunity in influenza

During the season when influenza is rampant, some people repeatedly fall ill, while others remain safe and sound. The key to this difference often depends on the strength of the immune system. Immunity acts like the body's "moat," not only defending against viral invasion but also playing a core role in health defense. Research shows that a robust immune system can effectively reduce the risk of infection, allowing the body to maintain a solid defense against viral threats. Therefore, strengthening the immune foundation is not only essential for resisting influenza but also an important guarantee for maintaining overall health.

Intestinal health is the cornerstone of immunity

The intestine is the largest immune organ in the body, housing about 70% of immune cells and serving as an important regulatory center for the body's immune function (DOI: 10.3390/nu13030886). Probiotics enhance intestinal immune function and reduce the invasion of pathogenic microorganisms by regulating the gut microbiota and maintaining microecological balance.

The gut microbiota is interconnected with the pulmonary immune system through the "gut-lung axis" (DOI: 10.1038/s41385-019-0160-6), regulating the host's immune response. Currently, more and more studies have found that dysbiosis of the gut microbiota can affect respiratory inflammation and lead to diseases such as allergic asthma and idiopathic pneumonia syndrome (DOI: 10.1080/1040841X.2016.1176988).

In recent years, many studies have verified that various probiotic strains can promote intestinal barrier function, strengthen epithelial cell connections, and increase the secretion of immunoglobulin A (IgA), enhancing mucosal immune responses. IgA can effectively prevent viruses from attaching to the respiratory or intestinal mucosa, reducing the risk of infections such as H1N1 (DOI: 10.1038/s41467-024-51182-3). Regular supplementation of probiotics can comprehensively enhance immunity starting from the gut, building a solid defense for health.

Xinoia isolates and cultivates probiotics from the ocean, human intestines, and fermented dairy products, and collaborates with the Ningbo Key Laboratory of Health Food and Marine Drugs and Ningbo University to jointly establish a probiotic strain library.Selecting numerous probiotic strains that can enhance immunity or effectively resist the invasion of viruses such as H1N1.

Xinoia | Lactobacillus acidophilus ATCC 4356

Many studies at home and abroad have shown that the S-layer protein of ATCC 4356 has the ability to inhibit the entry of H1N1 virus H9N2 subtype into dendritic cells (DOI: 10.3389/fcimb.2016.00137). ATCC 4356 and its S-layer protein are promising biological materials for preventing H9N2 influenza.

Figure 2 Schematic diagram of the inhibitory effect of S-layer protein of ATCC 4356 on H9N2 AIV

Xinoia | Streptococcus thermophilus GYX-8

Has patented functions such as improving gut microbiota structure and regulating the production of short-chain fatty acids.(CN 114672434 B)Can enhance immunity and establish a healthy intestinal homeostasis.

Figure 3 Changes in gut microbiota of GYX-8 in mice and changes in short-chain fatty acid levels

Xinoia | Lactobacillus acidophilus HN07

It can lower the levels of inflammatory cytokines TNF-α and IL-6, as well as the production of caspase-3, thereby reducing intestinal inflammation and intestinal cell apoptosis (DOI: 10.1016/j.jff.2018.05.045). For intestinal inflammation caused by H1N1, HN07 is capable of inhibiting intestinal inflammation and maintaining intestinal homeostasis.

Xinoia probiotic strainsAfter rigorous screening and scientific formulation, they possess excellent safety and stability, suitable for daily supplementation for all age groups, helping to optimize gut microbiota ecology, enhance intestinal barrier function, activate the immune defense system, and improve overall immunity.